Using UV-Responsive Nanoparticles to Provide In Situ Control of Growth Factor Delivery and a More Constant Release Profile from a Hydrogel Environment

K Bruggeman; M Zhang; N Malagutti; S Soltani Dehnavi; R Williams; A Tricoli; D Nisbet

Journal article

Using UV-Responsive Nanoparticles to Provide In Situ Control of Growth Factor Delivery and a More Constant Release Profile from a Hydrogel Environment

K Bruggeman, M Zhang, N Malagutti, S Soltani Dehnavi, R Williams, A Tricoli, D Nisbet

ACS Applied Materials and Interfaces | AMER CHEMICAL SOC | Published : 2022

DOI: 10.1021/acsami.1c24528

Abstract

Nanoparticles are popular delivery vehicles, but their diffusional release results in inconstant drug delivery. Here, we flatten the delivery profile into a more constant, zero-order profile. Brain-derived neurotrophic factor (BDNF) is attached to photoactive titanium dioxide nanoparticles and loaded into a nanofibrous self-assembling peptide (SAP) hydrogel. Different UV exposure conditions show three distinct profiles, including a counterintuitive decrease in release after UV exposure. We propose that the adsorption of the freed growth factor onto the hydrogel nanofibers affects release. Nanoparticles diffuse from the hydrogel readily, carrying the bound growth factor, but the freed growth ..

View full abstract

University of Melbourne Researchers

David Nisbet Author

Related Projects (1)

GENERATING MULTI-COMPONENT SCAFFOLDING TO INFLUENCE THE DIFFERENTIATION OF EMBRYONIC STEM CELLS

Nervous system diseases are debilitating and will develop in over 50 per cent of people at some time in their life. This project will develo..

Grants

Awarded by Australian Research Council

Funding Acknowledgements

Authors 4 and 5 contributed equally to this work (equal corresponding authors). This research was supported by funding from the National Health and Medical Research Council, Australia, and an Australian Research Council Discovery Project (DP130103131). K.B. was supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Postgraduate Scholarship Doctoral (PGS D) Award (PGSD3-454427-2014). A.T. was supported by an Australian Research Council (ARC) Future Fellowship (FT200100939). D.N. was supported by NHMRC Dementia Research Leadership Fellowship (GNT1135657). The Nano&Bio Facility within the LAB and NRL laboratories used for material characterization was funded by the MEC ANU infrastructure scheme for funding. Access to the facilities of the Center for Advanced Microscopy (CAM) with funding through the Australian Microscopy and Microanalysis Research Facility (AMMRF) is gratefully acknowledged. The majority of this work was included in Kiara Bruggeman's Ph.D. thesis at The Australian National University and is reproduced with her permission.<SUP>40</SUP>